- Ory, Kid
- Oryad (doom metal/symphonic metal group)
- Oryema, Geoffrey
- Orzabal, Roland
- OS (German duo)
- OS 101
- Os 3 do Nordeste
- Os Atuais
- Os Bardos
- Os Cretinos
- Os Mateadores
- Os Mulheres Negras
- Os Nativos (South-Brazilian gaucho music group)
- Os Nazarenos
- Os Pontos Negros
- Os Serranos
- Os The Darma Lóvers
- Os Tincoãs
- Os Últimos Românticos da Rua Augusta
- Os Vips
- Os Vips (Os Vips)
- OS101 (hardcore punk band)
- Osa (El Caco frontman Øyvind Osa's solo project)
- Osa, Liv Bernhoft (Norwegian actress)
- Osada Vida
- Osadebe, Stephen Osita, Chief
- Osaen
- Osage Tribe
- Osaka Flu
- Osaka Monaurail
- Osaka Popstar
- Osaka Punch (Australian rock band, formerly The Kidney Thieves)
- Osaka Syunkasyuto
- Osaki (jazz hop)
- Osaki, Nana starring Nakashima, Mika
- Osama GBS
- Osanna
- Osanzi
- Osasioo (Canadian RnB Artist)
- Osatia
- Osawa, Shinichi
- Osay (American rapper, singer-songwriter)
- Osborn Abigail
- Osborne (Todd Osborn)
- Osborne Brothers, The
- Osborne Brothers, The & Allen, Harley "Red"
- Osborne Brothers, The & Wiseman, Mac
- Osborne, Anders (US singer-songwriter)
- Osborne, Bertín
- Osborne, Bobby
- Osborne, David (Classical/covers pianist)
- Osborne, Jeffrey
- Osborne, Joan
- Osborne, Joan feat. Pavarotti, Luciano & East London Gospel Choir
- Osborne, Lee feat. Emery, Roxanne
- Osborne, Mary Pope
- Osbourne, Johnny (Jamaican reggae singer)
- Osbourne, Kelly
- Osbourne, Ozzy
- Osbourne, Ozzy & Osbourne, Kelly
- Osbourne, Ozzy feat. Beck, Jeff
- Osbourne, Ozzy feat. Clapton, Eric
- Osbourne, Ozzy feat. Infectious Grooves
- Osbourne, Ozzy feat. Iommi, Tony
- Osbourne, Ozzy feat. Iommi, Tony & Wu‐Tang Clan
- Osbourne, Ozzy feat. John, Elton
- Osbourne, Ozzy feat. McCready, Mike
- Osbourne, Ozzy feat. Miss Piggy
- Osbourne, Ozzy feat. Osbourne, Kelly
- Osbourne, Ozzy feat. Post Malone
- Osbourne, Ozzy feat. Primus
- Osbourne, Ozzy feat. Rhoads, Randy
- Osbourne, Ozzy feat. Was (Not Was)
- Osbourne, Ozzy feat. Wylde, Zakk
- Osbourne, Ozzy feat. Zappa, Dweezil
- Osbourne, Ozzy w/Therapy?
- Osbourne, Ozzy with Iommi, Tony & Wu‐Tang Clan
- Osbourne, Ozzy with Osbourne, Kelly
- Osbourne, Ozzy with Rhoads, Randy
- Osbourne, Ozzy with Therapy?
- Osbourne, Ozzy with Zappa, Dweezil
- Osbournes, The
- Osby, Greg (American jazz saxophonist)
- Osca
- Osca (Zak, Jesse, Joe, Tom - of Wednesbury)
- Oscar (UK musician Paul Nicholas)
- Oscar (romanian rapper)
- Oscar (early 90s group)
- Oscar + Martin
- Oscar and the Karma
