- Open Mike Eagle feat. Toy Light
- Open Mike Eagle feat.Brown, Danny
- Open Mind, The (68-73 UK psychedelic rock band)
- Open Minded
- Open Palms
- Open Sails
- Open Sea, The
- Open Season (Australian RAC band)
- Open Sky
- Open Skyz
- Open the Skies
- Open University, The
- Open, The
- OpenBSD
- Openside
- Opensouls
- Opera (Polish group)
- Opera (Italian hard trance project)
- Opera Australia
- Opera Diabolicus (Doom/Black/Death Metal Swedish Band)
- Opera Familia
- Opera IX
- Opera Magna
- OperaBabes
- Operación Triunfo (fake artist)
- Operación Triunfo 2017
- Operación Triunfo 2018
- Operación Triunfo, Academia
- Operadyse
- Operapop (Operatic pop duo)
- Operatica
- Operatika (symphonic metal)
- Operating Tracks, The
- Operation
- Operation Ivy
- Operation M.D, The
- Operation Mindcrime
- Operation Ratification
- Operation Winter Mist
- Operation, The
- Operation: Cliff Clavin
- Operator (Hard Rock Band)
- Operator Please
- Operator, Hello
- Operators (Canadian band)
- Operators, The (ska, from Indianapolis, IN)
- Operus
- Opeth (Swedish progressive metal/rock)
- Opgeduveld
- Opgezwolle
- Ophelia Ragtime Orchestra
- Ophelia's Eye (Melodic death metal band from Switzerland)
- Ophelias, The (psychedelic rock band from San Francisco)
- Ophelias, The (Cincinnati indie rock band)
- Ophidian (hardcore dj)
- Ophidian & Peacock, Dr.
- Ophidian & Playah, Tha
- Ophidian I
- Ophis (Germany, Metal)
- Ophthalamia
- Opi the Hit Machine
- Opia (indie electronic group: Cole Citrenbaum, DJ Stanfill and colorthought)
- Opiate for the Masses
- Opick
- Opio (Opion Lindsey - US rapper, from Souls of Mischief)
- Opium (Belgian all girl pop group)
- Opium du Peuple
- Opium Jukebox
- Opium Moon
- Opium Owl (heavy psych rock band from Riga, Latvia)
- Opium Warlords
- Opiuo (Australian electronica / breakbeat artist)
- Opiuo feat. Gift of Gab & Syreneiscreamy
- OPM (1999-current US dub pop hip-hop punk reggae group)
- OPM & Big B
- Opodebota
- Opossom (New Zealand)
- OPP
- Oppenheimer
- Oppenheimer Analysis
- Oppenheimer, Andy (member of Oppenheimer Analysis)
- Oppera
- Opposites, The
- Opposites, The feat. Adje
- Opposites, The feat. Faberyayo & Sjaak
- Opposites, The feat. Hydroboyz & Adje
- Opposites, The feat. Mr. Probz
- Opposites, The feat. Probz, Mr
- Opposites, The feat. Sef
- Opposites, The feat. Spasmatic
