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- SydSym
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- Sergey Nevone & O'Shine, Simon
- Sergey Nevone & O’Shine, Simon
- Serginho, MC
- Sergio Esquivel (mexican singer)
- Sérgio Mendes Trio
- Sergio Rafael Orchestra, The
- Sergio Salvatore
- Sergio Sylvestre (winner of "Amici 2015" in Italy)
- Sergio y Estíbaliz
- Sérgio, Paulo
- Serguei
- Serhat (Serhat Bedük)
- Serial (Podcast)
- Serial Hawk
- Serial Joe
- Serial Killaz (drum and bass / jungle)
- Serianna
- Series, Pickin' on
- Seriese, Astrid
- Šerifović, Marija
- Seringai
- Serino, Andrew
- Serious (US rapper)
- Serious Black (power metal band from Germany)
- Serious Klein
- Serious-M
- Serious, DJ
- Serjan (trance)
- Serk
- Serkin, Rudolf (pianist)
- Sermanni, Rachel
- Sermisy, Claudin de (composer)
- Sermon (Progressive metal)
- Sermon, Erick
- Sermon, Erick feat. Gaye, Marvin
- Sermon, Erick feat. Murray, Keith
- Sermon, Erick feat. Redman
- Sermon, Erick feat. Scott, Sy
- Serna, Alina
- Serna, Kevin di
- Serneholt, Marie
- Sero El Mero
- Sero.Overdose
- Serocs
- Serosia
- Serotonal
- Serpe, Gabriele
- Serpens Aeon
- Serpent (Swedish heavy / doom / hard rock)
- Serpent (Japanese melodic death metal band)
- Serpent (Swedish doom metal side project formed by Therion and Entombed members)
- Serpent Beat
- Serpent Obscene
- Serpent Omega
- Serpent Power (Feat. Ian Skelly (The Coral) and Paul Molloy (The Zutons))
- Serpent Power, The (60s folk/psychelic rock band from San Francisco)
- Serpenteens
- Serpenti (Italian band)
- Serpentina
- Serpentine (British Hard Rock Group)
- Serpentine Dominion (American Melodic Death Metal)
- Serpentine Path
- Serpentor
- serpentwithfeet (Josiahwise)
- serpentwithfeet
- serpentwithfeet
- Serph
- Serpico (Edinburgh, UK punk/metal band)
- Serra Lima, María Martha
- Serra, Anton
- Serra, Éric
- Serra, Jacobo
- Serrano, Héctor (Christian artist)
- Serrano, Ismael
- Serrano, José (Spanish composer)
- Serrano, Juan
- Serrano, Paco
- Serrano, Rosita
- Serras (Danish Folk Music)
- Serrat (Greenland/Danish band)
- Serrat, Joan Manuel
- Serrat, Joan Manuel & Sabina, Joaquín
- Serrat, Joan Manuel con Poveda, Miguel
- Serrat, Joana
- Serrie, Jonn
- Sers, Gauvain
- Sertab & Murat Uncuoglu & Aytekin Kurt
- Sertão Sangrento
- Sertraline
- Serú Girán
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