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- SylSyn
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- Special Pillow, The
- Special Request (1980s electro, key track "Salsa Smurf")
- Special Request (jungle alias of Paul Woolford)
- Special Request Horns
- Special Teamz
- Special-K (Icelandic musician)
- Special, Duke
- Specialist 'N' Tru Skool & Bhaniawala, Kaka
- Specialisterna
- Specialivery
- Specials, The (ska band)
- Specials, The feat. Rodriguez, Rico
- SpecialThanks
- Species (thrash metal band from Poland)
- Specifics
- Specii
- Specimen (UK glam/goth band)
- Speck Mountain
- Speckled Red
- Specktors (Danish rap band)
- Specktors feat. Smigg Dirtee
- Spectac & 9th Wonder
- Spectacle, The (Norwegian hardcore punk band)
- Spectacular Diagnostics (beats/instrumental hip hop)
- Specter, Dave & Bluebirds, The
- Spective
- Spector (London indie four-piece, formed 2011)
- Spector, Jarrod
- Spector, Phil
- Spector, Phil and Artists
- Spector, Ronnie
- Spector, Ronnie & E Street Band, The
- Spector, Ronnie & E Street Band, The
- Spector, Ronnie & Money, Eddie
- Spector, Ronnie and E Street Band, The
- Spector, Ronnie with Southside Johnny & The Asbury Jukes
- Spectoral (Andrew Bitto)
- Spectors, The (Belgian dreampop & shoegaze band)
- Spectra (Portugeese goa/trance project)
- Spectra (French Heavy/Thrash Metal)
- Spectral (German metal band)
- Spectral Display
- Spectral Souls (Peruvian death metal band)
- Spectral Wound
- Spectrals
- SpectraSoul
- SpectraSoul & dBridge
- SpectraSoul feat. McKenzie, Lily
- SpectraSoul feat. SOLAH
- SpectraSoul feat. Tamara Blessa
- SpectraSoul feat. Walker, Terri
- Spectre Hearts
- Spectre, Aaron
- Spectres (Vancouver punk band)
- Spectres, The (UK band, precursor to Status Quo)
- Spectrum (Belgian new beat/techno duo David Morley & Renaat Vandepapeliere)
- Spectrum (Brazilian psychedelic group)
- SPECTRUM (Japanese jazz fusion/rock band)
- Spectrum (Israeli psytrance/goa trio)
- SPECTRUM (South Korean boy band)
- Spectrum (contemporary Classical ensemble)
- Spectrum (UK space rock/psychedelic band)
- Spectrum-X
- Specxfic
- Specy Men (French Rapper)
- Spedding, Chris
- Spedding, Chris & Vibrators, The
- Spedding, Chris + Vibrators, The
- Spee, Lori
- Speech (US rapper & musician)
- Speech Debelle
- Speech Debelle feat. Roots Manuva & Realism
- Speech Patterns (Florida Post Hardcore)
- SPEECHLESS (instrumental hip‐hop artist)
- Speechwriters LLC
- SPEED (hardcore, Sydney, NSW, Australia)
- SPEED (Japanese group)
- SPEED (South Korean boy group)
- Speed 78
- Speed Freak, The
- Speed Gang (Michigan rapper)
- Speed Limit (Spanish dance project)
- Speed of Light
- Speed of Light (California garage rock)
- Speed of Sound in Seawater, The
- Speed Queen (Belgian speed metal band)
- Speed Queens (American 90ties punk/rock band)
- Speed Stroke (Sleazy hard rock band from Italy)
- Speed The Plough
- Speed, Ronski
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