- IRUKA
- Irusta, Agustín
- Irvine, Andy & Brady, Paul
- Irvine, Jeremy, James, Lily, Brosnan, Pierce & Seyfried, Amanda
- Irvine, Weldon
- Irving
- Irving Aaronson
- Irving Casanova (Regional Mexican)
- Irving Manuel
- Irving, Amy
- Irving, Catriona
- Irving, Lonnie
- Irwansyah
- Irwin, Ashton
- Irwin, Big Dee
- Irwin, Fred
- Irwin, Richard M.S.
- Irwin, Russ
- IRyS (hololive EN Project: HOPE)
- Is (Spanish indie pop)
- Is (Black Metal from Russia)
- IS TROPICAL
- Is/Is
- Is0kenny (New Jersey rapper)
- Isa (Swedish singer Isa Tengblad)
- Isaac (hardstyle artist)
- Isaac Adni
- Isaac Burdiss
- Isaac Delusion (French pop band)
- Isaac Green And The Skalars
- Isaac Stuart
- Isaac Zale (fka Zac Flewids)
- Isaac, DJ (hardcore/hardstyle DJ & producer)
- Isaac, DJ feat. Wildstylez
- Isaac, Greta
- Isaac, Heinrich (Flemish Renaissance composer)
- Isaac, Ismaël
- Isaac, Jake
- Isaac, Jamie (bedroom producer)
- Isaac, Sam
- Isaacs, David
- Isaacs, Gregory
- Isaacs, Gregory & Brown, Dennis
- Isaacs, Pamela
- Isaacs, Sonya (American country and Christian music singer)
- Isaacs, The
- Isaacson, Ella
- Isaak, Chris
- Isabel (German pop vocalist Isabel Soares)
- Isabel Marco
- Isabel Suckling (vocal)
- Isabela (Isabela, cantante sinaloense)
- Isabell Schmidt
- ISABELLA (Isabella Peschardt)
- Isabella, Kira
- Isabelle A (Belgian singer, Isabelle Adam)
- Isabelle Brown
- Isabelle, Ana
- Isacaarum (Czech grindcore)
- Isacowitz, Maya
- Isadar
- Isador (Warren Heller)
- Isai Morales (Male solo artist)
- Isaiah, Cameron (artist, lyricist)
- Isaiah, Daniel
- Isak (Swedish singer-songwriter born in the 1970s)
- Isak (fuzz/stoner rock band from Glasgow, Scotland)
- Isak Strand vs. TOE
- Isakoatl
- Isakov, Gregory Alan
- Isaksson, Patrik
- Isaksson, Patrik & Dawn Finer, Sarah
- Isaksson, Patrik & Dea
- Isaksson, Patrik & Sjöholm, Helen
- Isaksson, Patrik, Moraeus, Kalle & Jansson, Bengan
- Isam B (Danish singer of Moroccan descent)
- Isan
- Isasa (Spanish composer, guitarist)
- Isatha
- isaur
- Isaurian
- Isayama, Mio
- Isbell, Jason
- Isbell, Jason & 400 Unit, The
- Isbell, Jason & Shires, Amanda
- Isbell, Jason and 400 Unit, The
- Isbell, Jason and the 400 Unit
- Isbell, Jason and the 400 Unit feat. Fleck, Béla & Thile, Chris
- Isbell, Jason and the 400 Unit feat. Shires, Amanda
- Isbells (Belgian indie/neofolk group)
