- IShowSpeed
- Ishq (Downtempo and electronica group)
- Ishtar
- Ishtar (French-Israeli vocalist, singer of Alabina)
- Ishtar (Korean metal group)
- Ishutin, Anton
- Isiah Shaka
- Isiah, Ian
- Isidore
- Isidro, Agot
- Isioma, Serena
- Isis (Experimental post-metal band from Boston, USA)
- Isis (Lin Que)
- Isis ('70s All Woman Rock Band)
- ISIS (Mexican rock and pop band)
- Isis + Aereogramme
- Isis Gee
- Isis Regina
- Işıklı, Toygar
- Işılak, Uğur
- Išjunk šviesą
- ISK (French rapper)
- ISK feat. DA Uzi
- ISK feat. Niro
- ISK feat. Sofiane
- ISK feat. UZI
- Iskald
- Iskander (Latin Pop)
- Iskaz
- İskender, de
- Iskra (Canadian anarchist crust punk band)
- IsKwé
- Isla de Caras
- Isla de los Estados
- Isla Invisible
- Isla Mujeres (female indie electronic band from Argentina)
- Isla San Juan
- Isla, Connie
- Isla, Rae
- Islam, Rupam
- Islam, Syed Shahidul & Kheya
- Islam, Yusuf (formerly Cat Stevens)
- Islam, Yusuf / Stevens, Cat
- Islam, Yusuf feat. Ben Ammi
- Islamović, Alen
- Island (German metal band)
- ISLAND (from London)
- Island (Wannes Van De Velde; Paul Rans; Dirk Van Esbroeck; ... (et al.))
- Island Apollo
- Island Caribbean Steel Drum Band
- Island Inspirational All-Stars, The
- Island, Dre (Reggae singer)
- Island, Dre feat. Jean, Wyclef
- Island, Dre feat. Popcaan
- Island, Five Mile
- Islander (Rock Band)
- Islander feat. H.R.
- Islander feat. Sandoval, Sonny
- Islandica
- Islandis (Sydney Indie-Pop Duo.)
- islandman
- Islands (indie rock band from Montreal, Canada)
- Islands (post-metal band from Sydney, Australia)
- ISLE (Scottish Band)
- isle & fever
- Isle Ate Her, An (grindcore band)
- Isle of Avalon
- Isle Of CC, The
- Isle of Q
- Íslensku dívurnar
- Isles (US/ San Francisco heavy rock band)
- Isles & Glaciers
- Isles, Keil, The
- Isles, The
- Isley Brothers, The
- Isley Brothers, The feat. Beyoncé
- Isley Jasper Isley
- Isley, Alex
- Isley, Ronald (a.k.a. Mr. Biggs)
- Isley, Ronald feat. Franklin, Aretha
- Isley, Ronald feat. Trey Songz
- Isleym
- Isma‐Ae, Jerome & Alastor feat. London Thor
- Isma‐Ae, Jerome with Cosmic Gate
- Ismael Ayende (Colombian Latin alternative band)
- Ismael, Claudio (Kizomba artist)
- Ismag, Tim
- İsmail YK
- Ismail, Lobo
- Ismail, Saalim (Music Artist & Certified Transformation Life Coach from Cape Town, South Africa)
