- Isley, Melinda
- Isley, Ronald (a.k.a. Mr. Biggs)
- Isley, Ronald feat. Franklin, Aretha
- Isley, Ronald feat. Trey Songz
- Isleym
- Isma‐Ae, Jerome & Alastor feat. London Thor
- Isma‐Ae, Jerome with Cosmic Gate
- Ismael Ayende (Colombian Latin alternative band)
- Ismael, Claudio (Kizomba artist)
- Ismag, Tim
- İsmail YK
- Ismail, Saalim (Music Artist & Certified Transformation Life Coach from Cape Town, South Africa)
- Ismajli, Adelina
- Ismen (Swedish hip hop)
- Ismeros Arcok
- Ismo Alanko Säätiö
- Ismo Alanko Teholla (Ismo Alanko and Teho Majamäki's project.)
- Ismo, Lijpe x
- Isn't It Always?
- Iso H
- ISO Indies
- Iso, King (Tarrel C. Gulledge)
- Iso, King feat. Daylyt
- Iso, King feat. King Kash & Snake Lucci
- Iso, King feat. Rittz & Twista
- Isocel
- Isoir, André (organist)
- Isolate.exe (phonk music)
- Isolated (~Johannes Gräf & Marcel Güntner)
- Isolated Corners
- Isolated Youth
- Isolation Berlin
- Isolation Years
- Isolation, In
- Isole
- Isolée
- Isomer, Sin
- isomonstrosity
- ISON (Cosmic drone from Sweden)
- Ison & Fille
- Ison & Fille feat. Amin
- Ison & Fille feat. Amin & Sseruwagi, Mogge
- Ison & Fille feat. Fre & Sseruwagi, Mogge
- Ison & Fille feat. Highwon
- Ison & Fille feat. Meles, Nebay & Rosh
- Ison & Fille feat. Zarate, Michelle
- IsOokSchitterend
- Isoscope
- Isosine
- Isostatic (ambient project aka Sean Costello)
- Isotope
- Isotope Soap
- Isotopes (Sydney, Aus. Melodic Hardcore)
- Isoul8
- Isović, Safet (Bosnian Folk singer)
- ISOxo (San Diego producer/dj)
- ISOxo & Ninajirachi
- Ispolins
- Israel (1990s US Christian pop)
- Israel (probably australian hiphop)
- Israel & New Breed
- Israel & New Breed feat. Adams, Yolanda
- Israel & New Breed feat. McReynolds, Jonathan
- Israel & New Breed feat. Neal, Charlin
- Israel & New Breed feat. Putnam, BJ
- Israel & New Breed feat. T-Bone
- Israel & New Breed feat. Tribbett, Tye
- Israel & Rodolffo
- Israel & Rodolffo & Juliette
- Israel & Rodolffo & Kevinho
- Israel & Rodolffo & Mari Fernandez
- Israel & Rodolffo part. Humberto & Ronaldo
- Israel & Rodolffo part. Lima, Gusttavo
- Israel & Rodolffo part. Matheus & Kauan
- Israel B
- Israel B & Lowlight
- Israel Fernández
- Israel Fernández y Diego del Morao
- Israel Novaes
- Israel Philharmonic Orchestra (Israeli orchestra)
- Israel Vibration
- Israel, Dan
- Israel, Jake
- Israel, Joseph
- Israelites, The (USA Christian Ska)
- Israelsson, Karl-Erik
- Issa (Norwegian Singer)
- Issa Gold (The Underachievers)
- Issa, Sámer
- Issaba (Rappeur fr)
