- Upchurch, Phil, Combo
- updog
- Upercent (Valencian DJ/producer José Molés Martínez)
- Upfux, The (New Jersey Ska band)
- Upgrade (NY hip-hop)
- Upgrade (Psychedelic trance duo from Israel [Raz Kfir & Udi Pilo])
- Upgrade (DnB/dubstep producer/engineer from Norwich)
- Upheaval (French Technical/Brutal Death Metal)
- Upiór (Symphonic death metal from France)
- Upjohn, Jed
- UPLIFT SPICE
- Uplift, Ori
- Uplink (house)
- Uplink & Skrindo, Alex feat. Axol
- upnow
- Upon a Burning Body
- Upon a Red Sky
- Upon the Water (Metalcore Band)
- Upon the Water & Russell, Garrett
- Upon This Dawning
- Upon Wings
- Upon Your Dead Body
- Uponcue
- Upper Class (house duo, active around the turn of the millennium)
- Upper Crust, The (U.S. hard rock band from Massachusetts)
- Upper Room, The
- Upper Structure
- Upper Tunist, The
- Upper West
- UPPERCASE
- Uppermost
- Uppermost feat. Birsen
- Uppermost feat. Mesita
- Uppermost feat. Pane, Harry
- Uppermost feat. Sôra
- Uppermost feat. SYML
- UPPERROOM
- UPPERROOM feat. Figueroa, Joel
- UPPERROOM, Figueroa, Joel
- UPPERROOM, Gamboa, Abbie
- UPPERROOM, Gamboa, Abbie, Lewis, Jonathan
- UPPERROOM, Jenkins, Aiva
- UPPERROOM, Mauldin, Meredith
- UPPERROOM, Smith, Elyssa
- UPPERROOM, Smith, SarahBeth
- Uppertones, The
- Upright Citizens
- Upright Forms (noise rock from Minneapolis)
- Upright T‐Rex Music
- Uprise, The (Canadian band)
- UPRISING (pittsburgh hardcore punk)
- UPRISING featuring Rice, Candrika
- Uprizal
- Uproar (UK Trance - Also known as: BCD Project, Hardnox, King Of Clubs)
- UPROAR!!
- Uprooted
- Ups & Downs
- UPSAHL
- UPSAHL & Absofacto
- UPSAHL feat. blackbear
- UPSAHL feat. Lay Bankz
- UPSAHL feat. Two Feet
- Upset (US band, formed 2013)
- Upset Victory, The (US rock band)
- Upsetter (Brisbane punk band)
- Upsetters, The (Lee Perry's reggae house band)
- Upshaw, Dawn (soprano)
- Upside Down Man
- Upside Down Room
- Upside, The
- Upsided, The
- Upsidedown Cross
- Upsidedown, The
- upsidedownhead
- upsidedownhead & Clea
- upsidedownhead feat. Ric Rufio
- Upsilon (French rapper)
- Upsilone
- Upsilone, Keeble, Eloise
- Upstairs, The (Indonesian rock band)
- UpstairsPeople
- Upstanding Youth
- Upstate (based out of Blackwatch Studios)
- Upstate (Poughkeepsie, New York band)
- Upstate Rubdown (Appalachian Soul)
- Upstream Drifters
- Upstrz (r&b singer/songwriter)
- Upton, Jason
- Upton, Pat
- Uptones, The
