- Untouchables, The (60s/70s UK reggae on Trojan, single "Tighten Up")
- Untouchables, The (UK drum and bass duo, Dean Vincent & Kraig Martin)
- Untouchables, The (house artist Kenny Dope)
- Untouchables, The (Belgian drum and bass duo)
- Untsakad
- Untung Sonjaya
- Unturned
- Unusual Cosmic Process (Downtempo artist)
- Unusual Demont
- Unusual Suspects (UK hip hop)
- Unveil
- Unveil Raze
- Unveil The Strength
- Unverkalt
- Unviar
- UNVS
- Unwanted Superheroes
- Unwanted, The (Irish Band)
- Unwed Mothers
- Unwed Sailor
- Unwell (Ambient/drone/experimental electronic music artist Daniel Holideigh)
- UNWELL (Rock/pop-punk band)
- Unwind, DJ (American Producer & Remixer)
- Unwinding Hours, The (Scottish alternative rock band)
- UNWISH
- Unwoman
- Unword
- Unworthy (Southern California Deathcore)
- Unwound (US post‐hardcore band)
- Unwrapped (hip‐hop songs covered in jazz style)
- Unwritten Law (1990- current American rock band)
- Unwritten Pages
- Unya (Finnish band)
- Unyielding Love (Grindcore/experimental band from Belfast, Northern Ireland)
- Unzane
- Unzucht
- Unzucht feat. Grunewald, Dave
- Unzucht feat. Harms, Chris
- Unzucht feat. Saltatio Mortis
- Unzyme
- Uochi Toki (Italian hip-hop band)
- Uochi Toki / Eterea Post Bong Band
- Uomini di mare
- Uomo, Billy
- Uoti, Henna
- Up & Down
- Up Close
- Up dharma Down
- Up Dharma Down
- Up for Nothing
- Up From Here
- Up from Here (Pop Punk)
- Up Front
- Up North Session Orchestra
- Up To Eleven (Romanian Alt. Rock Group)
- Up Up Down Down Left Right Left Right B A Start
- Up Up Girls (Kakko Kari)
- Up With People
- Up With People (Up With People! was the international educational and cultural organization which aims to encourage understanding among people of all nations.)
- UP-BEAT
- Up, $kin
- Up, Ari
- Up, Bustle & Out
- Up, Bustle & Out with Sam, Şevval
- UP! (Richie Hawtin)
- UP! (Hungarian band)
- UP10TION
- UPA Dance
- Upa!
- Upadhyay, Harsh
- Upadhyay, Purushottam
- UPAFTER, The
- Upbeat, The
- Upbeats, The (New Zealand drum n bass duo)
- Upbeats, The & Shapeshifter
- Upbeats, The feat. Baxter, Tasha
- Upbeats, The feat. Fisher, Georgie
- Upbeats, The feat. Joe Dukie
- Upbeats, The feat. Mara TK
- Upbeats, The feat. Worboys, Ned
- Upchuck (Atlanta punk)
- Upchurch (country rapper)
- Upchurch & Hosier, Chris
- Upchurch & Noel, Katie
- Upchurch & The Dixielanders
- Upchurch and Jones, Demun
- Upchurch feat. Mama Church
- Upchurch feat. Merkules & Jelly Roll
- Upchurch feat. Rizzi Myers
- Upchurch, Phil
