- Unwritten Law (1990- current American rock band)
- Unwritten Pages
- Unya (Finnish band)
- Unyielding Love (Grindcore/experimental band from Belfast, Northern Ireland)
- Unzane
- Unzucht
- Unzucht feat. Grunewald, Dave
- Unzucht feat. Harms, Chris
- Unzucht feat. Saltatio Mortis
- Unzyme
- Uochi Toki (Italian hip-hop band)
- Uomini di mare
- Uomini in frac
- Uomo, Billy
- Uoti, Henna
- Up Close
- Up dharma Down
- Up Dharma Down
- Up for Nothing
- Up From Here
- Up from Here (Pop Punk)
- Up Front
- Up Hygh
- Up North Session Orchestra
- Up To Eleven (Romanian Alt. Rock Group)
- Up Up Down Down Left Right Left Right B A Start
- Up Up Girls (Kakko Kari)
- Up With People
- Up With People (Up With People! was the international educational and cultural organization which aims to encourage understanding among people of all nations.)
- UP-BEAT
- Up, $kin
- Up, Ari
- Up, Bustle & Out
- UP! (Hungarian band)
- UP10TION
- UPA Dance
- Upa!
- Upadhyay, Harsh
- Upadhyay, Purushottam
- UPAFTER, The
- upallnight (Vaporwave artist)
- Upbeat, The
- Upbeats, The (New Zealand drum n bass duo)
- Upbeats, The & Shapeshifter
- Upbeats, The feat. Baxter, Tasha
- Upbeats, The feat. Fisher, Georgie
- Upbeats, The feat. Joe Dukie
- Upbeats, The feat. Mara TK
- Upbeats, The feat. Worboys, Ned
- Upchuck (Atlanta punk)
- Upchurch (country rapper)
- Upchurch & Hosier, Chris
- Upchurch & Noel, Katie
- Upchurch & The Dixielanders
- Upchurch and Jones, Demun
- Upchurch feat. Mama Church
- Upchurch feat. Merkules & Jelly Roll
- Upchurch feat. Rizzi Myers
- Upchurch, Phil
- Upchurch, Phil, Combo
- updog
- Upercent (Valencian DJ/producer José Molés Martínez)
- Upfront
- Upfux, The (New Jersey Ska band)
- Upgrade (NY hip-hop)
- Upgrade (Psychedelic trance duo from Israel [Raz Kfir & Udi Pilo])
- Upgrade (DnB/dubstep producer/engineer from Norwich)
- Upiór (Symphonic death metal from France)
- Upjohn, Jed
- UPLIFT SPICE
- Uplift, Ori
- Uplink (house)
- Uplink & Skrindo, Alex feat. Axol
- upnow
- Upon a Burning Body
- Upon a Red Sky
- Upon the Water (Metalcore Band)
- Upon the Water & Russell, Garrett
- Upon This Dawning
- Upon Your Dead Body
- Uponcue
- UPP
- UPP - UPP
- Upper Class (house duo, active around the turn of the millennium)
- Upper Crust, The (U.S. hard rock band from Massachusetts)
- Upper Room, The
- Upper Structure
- Upper Tunist, The
- Upper West
- UPPERCASE
