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- LZILzy
- Lewis, Dominic (British score composer)
- Lewis, Donna
- Lewis, Ed (jazz trumpeter)
- Lewis, Ephraim (soul singer and songwriter)
- Lewis, Erika (blues and folk vocalist, notably with Tuba Skinny)
- Lewis, Evan
- Lewis, Freddie (trans pop artist)
- Lewis, Furry
- Lewis, Furry (American country blues guitarist)
- Lewis, Gary & the Playboys
- Lewis, George (New Orleans jazz clarinetist)
- Lewis, Glenn (Canadian neo soul singer/songwriter)
- Lewis, Hannah Jane (pop singer)
- Lewis, Herschell Gordon
- Lewis, Hopeton
- Lewis, Huey
- Lewis, Huey & News, The (Rock . Pop . Top 40)
- Lewis, Huey and News, The feat. Wynonna
- Lewis, Huey and the News (American pop rock band)
- Lewis, Huey and the News & Judd, Wynonna
- Lewis, Jack (US anti-folk musician)
- Lewis, Jamie
- Lewis, Jamie & Pippi, DJ
- Lewis, Jamie & Pippi, DJ feat. Cooper, Kim
- Lewis, Jamie & Watford, Michael
- Lewis, Jayce
- Lewis, Jeffrey
- Lewis, Jeffrey & Bolts, Los
- Lewis, Jeffrey & Junkyard, The
- Lewis, Jeffrey & Lewis, Jack
- Lewis, Jeffrey & The Voltage
- Lewis, Jenifer feat. Pinnacle Gospel Choir, The
- Lewis, Jenny (US actress and musician)
- Lewis, Jenny with Watson Twins, The
- Lewis, Jerry (US actor, comedian and occasional singer)
- Lewis, Jerry Lee (Rock & Roll pianist, nicknamed “The Killer”)
- Lewis, Jerry Lee & Lewis, Linda Gail
- Lewis, Jerry Lee feat. Fogerty, John
- Lewis, Jerry Lee feat. Nelson, Willie
- Lewis, Jerry Lee feat. Richards, Keith
- Lewis, Jerry Lee with Fogerty, John
- Lewis, Jerry Lee with Henley, Don
- Lewis, Jerry Lee with Jagger, Mick & Wood, Ron
- Lewis, Jerry Lee with Jones, George
- Lewis, Jerry Lee with King, B.B.
- Lewis, Jerry Lee with Kristofferson, Kris
- Lewis, Jerry Lee with Little Richard
- Lewis, Jerry Lee with Nelson, Willie
- Lewis, Jerry Lee with Page, Jimmy
- Lewis, Jerry Lee with Robertson, Robbie
- Lewis, Jerry Lee with Springsteen, Bruce
- Lewis, Jerry Lee with Stewart, Rod
- Lewis, Jerry Lee with Young, Neil
- Lewis, Jimmy (Soul/Blues singer/songwriter/producer)
- Lewis, Jodee
- Lewis, Joe (US techno/acid house producer)
- Lewis, John (pianist, member of Modern Jazz Quartet)
- Lewis, Jon Peter
- Lewis, Juliette (actress)
- Lewis, Ksenia
- Lewis, Laurie (bluegrass artist and violinist)
- Lewis, Laurie & Right Hands, The
- Lewis, Laurie and Rozum, Tom
- Lewis, Leon
- Lewis, Leona
- Lewis, Leona / Avicii
- Lewis, Leona feat. Allen, Robert
- Lewis, Leona feat. Childish Gambino
- Lewis, Leona feat. K2 Family
- Lewis, Leona feat. Loot
- Lewis, Leona featuring Ne‐Yo
- Lewis, Lesle
- Lewis, Lilli
- Lewis, Linda
- Lewis, Linda Gail
- Lewis, LunchMoney
- Lewis, Marcia
- Lewis, Margaret
- Lewis, Meade Lux
- Lewis, Mel (American jazz drummer)
- Lewis, Michelle (singer-songwriter)
- Lewis, Molly (Australian alternative artist)
- Lewis, Monica
- Lewis, Olivia
- Lewis, Parker
- Lewis, Phil (heavy metal vocalist)
- Lewis, Quinn
- Lewis, Ramsey
- Lewis, Ramsey & Wilson, Nancy
- Lewis, Ramsey, Trio, The