- ISHA (Belgian rapper, formerly known as "Psmaker")
- ISHA & OG Gold
- Isham Jones Orchestra
- Isham, Mark (American musician and score composer)
- Ishan
- Ishawna (Singer)
- IshDARR (rapper us)
- iSHi (Swedish producer)
- Ishi (Dallas Based Electro-Folk Band)
- iSHi feat. Bao, Noonie
- iSHi feat. Ku, Georgia
- iSHi feat. Prince Prime
- iSHi feat. Raekwon
- iSHi feat. S, Astrid
- iSHi feat. Soleil Camara
- iSHi feat. Tempah, Tinie & Pusha T
- iSHi feat. Tither, Grace
- Ishibashi, Eiko
- Ishida, Keiko
- Ishida, Yoko
- Ishihara, Kaori
- Ishii, Akemi
- Ishii, Tatsuya (singer-songwriter, artist & industrial designer)
- Ishikawa, Chiaki
- Ishimoto, Takeharu
- Ishino, Takkyu
- Ishiwatari, Daisuke
- Ishizaki, Huwie
- Ishmael
- Ishmael Ensemble
- Ishome (Mira Ishome)
- Ishome (Mirabella Kiryanova)
- IShowSpeed
- Ishq (Downtempo and electronica group)
- Ishq Bector
- Ishtar
- Ishtar (French-Israeli vocalist, singer of Alabina)
- Ishtar (Korean metal group)
- Ishtar feat. Tchanelas
- Ishtar feat. Tchanelas & Mc Fly
- Ishutin, Anton
- Isiah Shaka
- Isiah, Ian
- Isidore
- Isidro, Agot
- Isildurs Bane & Hogarth, Steve
- Isioma, Serena
- Isis (Experimental post-metal band from Boston, USA)
- Isis (Lin Que)
- Isis ('70s All Woman Rock Band)
- ISIS (Mexican rock and pop band)
- Isis + Aereogramme
- Isis Gee
- Isis Regina
- Işık, Selim
- Işıklı, Toygar
- Işılak, Uğur
- Išjunk šviesą
- ISK (French rapper)
- ISK feat. Alonzo
- ISK feat. DA Uzi
- ISK feat. Niro
- ISK feat. Sofiane
- ISK feat. UZI
- Iskald
- Iskanbila
- Iskander (Latin Pop)
- Iskaz
- İskender, de
- ISKO (Singer/songwriter)
- iskwē
- iskwē & Wilson, Tom
- ISLA (Josh Rouse)
- Isla de Caras
- Isla de los Estados
- Isla Invisible
- Isla Mujeres (female indie electronic band from Argentina)
- Isla Noir
- Isla San Juan
- Isla, Connie
- Isla, Rae
- Islaja
- Islam, Rupam
- Islam, Syed Shahidul & Kheya
- Islam, Yusuf (formerly Cat Stevens)
- Islam, Yusuf / Stevens, Cat
- Islam, Yusuf feat. Ben Ammi
- Islamia School Kids (UK)
- Islamović, Alen
- ISLAND (from London)