- 2CELLOS feat. John, Elton
- 2CELLOS feat. Rivera, Naya
- 2CELLOS feat. Zucchero
- 2CELLOS, London Symphony Orchestra
- 2Cents
- 2charm (indie techno pop duo)
- 2cheesemilkshake
- 2cztery7
- 2cztery7 feat. Ciech & Eldo
- 2cztery7 feat. Lerek
- 2cztery7 feat. Pacak, Piotr
- 2cztery7 feat. Sosh
- 2D (Indonesian pop group)
- 2DB (Simon "Bassline" Smith & Andy Wright)
- 2DCAT
- 2DCAT & HAEZL
- 2DEAD BOYZ, Flatbush Zombies, Meechy Darko & Zombie Juice
- 2econd Class Citizen feat. Ceschi
- 2ersitz
- 2ersitz & Haller
- 2EYES (South Korean girl group)
- 2Faces (canadian hip hop)
- 2far2jump
- 2FarAway & Savor, Chris
- 2Fast 4You (Italian Eurodance band)
- 2FeetBino
- 2forwOyNE (Louisville, Kentucky-based music producer)
- 2fox
- 2fox feat. Nandi
- 2Frères (Quebec folk duo)
- 2Friends
- 2gaudy
- 2gaudy feat. DC THE DON
- 2geeked (Rapper)
- 2Gether
- 2Grés Nord (French rap)
- 2hermanoz
- 2hollis
- 2Hooks (Composers/Producers for Film & TV)
- 2Hounds
- 2HRs
- 2hug
- 2Hurt (Italian band)
- 2i, Lil
- 2Icons
- 2KBABY
- 2KBABY & Marshmello
- 2KBABY feat. G Herbo
- 2KBABY feat. Lil Durk
- 2KBABY feat. YFN Lucci
- 2KE & 808iuli
- 2Kvėpavimas (Lithuanian dance‐pop artist)
- 2Kvėpavimas & Bäsello
- 2Kvėpavimas × Adrina
- 2Kvėpavimas feat. Adrina
- 2Kvėpavimas ft. Iglė
- 2L & Nouvelle École
- 2LADE (German rapper)
- 2lane (Mozambican DJ)
- 2LATE
- 2loop (Deep House by Igor Matsagorov)
- 2lson
- 2M (japanese)
- 2manydjs
- 2matt (Actuality name artist)
- 2Méga
- 2Mex
- 2Mex feat. Murs & Ariano
- 2morrows June
- 2NB
- 2ND (US rock / metal)
- 2nd Chapter of Acts
- 2nd Exit (Lester Duval & Alfa Mist)
- 2nd Exit & Thomas‐Dyke, Kaya
- 2nd Face
- 2nd Generation Wu
- 2nd Grade
- 2nd II None (Rap duo from Compton, Los Angeles)
- 2nd II None feat. AMG & Quik, DJ
- 2nd Life, Svniivan & Drunken Bunny
- 2nd Life, Svniivan & Salvo
- 2nd Moon
- 2nd Nature (Ruud Van Rijen)
- 2nd Nature (Male R&B quartet from Seattle, Washington.)
- 2nd Roof (italian hip hop producers)
- 2nd Season (Russian punk-pop group, Max +100500)
- 2nd Shift
- 2nd South Carolina String Band
- 2nd Today (alt-rock from Greensboro, NC)
- 2NE1
